Hdn supplementation to geninduced rats significantly decreased serum urea, uric acid. Introduction gentamicin is an e ective aminoglycoside antibiotic against serious gramnegative bacterial infections. Thirtyfive spraguedawley rats were divided into 5 groups to receive saline. Apr 18, 2019 aminoglycoside induced ototoxicity is usually irreversible. Animals were injected during 4 or 10 days with saline nacl.
Environmental issues aminoglycosides antioxidants antioxidants nutrients cinnamon health aspects laboratory rats materia medica, vegetable plant extracts rats as laboratory animals. However, there are still controversies and speculation about the precise mechanism of action. Hyperbaric oxygen treatment and nephrotoxicity induced by gentamicin in rats matitiahu berkovitch1,2, yossi shain1,2, eran kozer1,2, michael goldman1,2 and ibrahim abukishk1,2 abstract background. Vitamin bcomplex dosedependently ameliorated gentamicin induced nephrotoxicity in adult swiss albino rats when given intramuscularly. Although the rates of aki we observed are similar to other reported rates of gentamicin nephrotoxicity, 1,2,5,1012 it is clear that these rates are higher than in some studies, which in part may be due to differing definitions of nephrotoxicity. Original article, report by advances in environmental biology.
The activities of lactate dehydrogenase and alkaline phosphatase were higher in rats treated with gentamicin than in control rats and were reduced by the treatment with tr. Inhibitory effect of olive leaf extract on gentamicin. Gentamicin induced acute renal damage and its evaluation using. The present study was designed to determine the protective effect of salicylic acid sa in gentamicininduced nephrotoxicity in rats. Gentamicininduced acute renal failure model creative. Comparative study on gentamicin and streptomycin induced nephrotoxicity in rats world small animal veterinary association world congress proceedings, 2004 m.
Gentamicin, bcomplex, swiss albino rats, nephrotoxicity, serum urea and creatine. Administration of nigella sativa extract prevented gentamicininduced nephrotoxicity in rats by reducing renal oxidative stress and enhancing antioxidant defense mechanism. Some antioxidant agents that have been used to ameliorate gentamicin induced nephrotoxicity in rats. Nephrotoxicity is a serious side effect of gentamicin and is believed. Renal protective effect of hesperidin on gentamicininduced. Gentamicin gm induced nephrotoxicity may be sex hormones related. Although the exact mechanism of gentamicininduced nephrotoxicity is not well. Finally, gentamicin nephrotoxicity is potentiated by magnesium depletion 27. Protective effect of pongamia pinnata flowers against.
Apr 12, 2012 the present study investigated the protective effects of melatonin mt against gentamicin gm induced nephrotoxicity and oxidative stress in rats. The effect of fleroxacin on gentamicininduced nephrotoxicity was evaluated with female spraguedawley rats. Effect of normobaric hyperoxia on gentamicininduced. Inhibitory effects of cinnamon extract on gentamicininduced nephrotoxicity in mail adult wistar rats. We studied gentamicin susceptibility of kidneys infected with e. Gentamicin is an important aminoglycoside antibiotic that is commonly used in serious and life. The effect of fleroxacin on gentamicininduced nephrotoxicity was evaluated with. Antioxidants, gentamicin, hesperidin, nephrotoxicity, oxidative stress. Nephrotoxicity was induced in rats by injecting gentamicin intramuscularly i.
The aim of this study was to evaluate the effect of subacute administration of propylthiouracil ptu on gentamicin gminduced nephrotoxicity in male rats. Nephrotoxicity was induced in wistar rats by intraperitoneal administration of gentamicin 100 mgkgday for eight days. Protective effect of crocin on gentamicininduced nephrotoxicity in rats. Ethanolic extract of garlic for attenuation of gentamicininduced nephrotoxicity in wistar rats hamid nasri,1 mehdi nematbakhsh,1 mahmoud rafieiankopaei2 introduction. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of serious infections, and the nephrotoxic adverse effect is one of the main therapeutic limitations. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. The present study investigated the protective effects of melatonin mt against gentamicin gminduced nephrotoxicity and oxidative stress in rats. Rats subjected to gentamicin induced nephrotoxicity, treated with pioglitazone at dose of 0. Protective effect of apocynin against gentamicininduced. Multiple factors may increase the nephrotoxic potential of aminoglycosides. Thus, this property of drugstoxin is utilized by investigators to induce disease models for clinical research of potential drugs as well as to study the pathogenesis of. Hyperbaric oxygen treatment and nephrotoxicity induced by.
The aim of this study was to evaluate the effect of subacute administration of propylthiouracil ptu on gentamicin gm induced nephrotoxicity in male rats. The effect of manganese chloride on gentamicininduced. In recent years gentamicin nephrotoxicity is significantly reduced by shifting to once daily dosage as well as by eliminating known risk factors. The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicininduced histopathologic changes in renal tissue were examined in rats. Does propylthiouracil increase the gentamicininduced. M in gml for the various invitro antioxidant models was determined by regression analysis. Gentamicininduced aki was established in female spraguedawley rats. Gentamicin induced nephrotoxicity was indicated by the reduced renal function and renal oat3 function and expression. Pdf protective effect of nebivolol on gentamicininduced. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Effect of ethanolic and aqueous extracts of bauhinia.
Influence of spironolactone treatment on gentamicin. Introduction gentamicin is an aminoglycoside antibiotic widely used for the treatment of bacterial infections. Cimetidine appears to have protective effect on gentamicin losartan induced nephrotoxicity in rats. Nephrotoxicity, gentamicin, astaxanthin, oxidative stress. Serum concentrations of aminoglycosides should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels. Effect of dimethyl sulfoxide on gentamicininduced nephrotoxicity in rats. Figure 2b and sod figure 2c activities in rat kidney homogenate. Pdf protective effect of quercetin against gentamicin.
Renal protective effect of hesperidin on gentamicin. Treated animals demonstrated a typical pattern of nephrotoxicity characterized by increased serum creatinine and urea. Materials and methods forty eight female rats were divided into 6 groups n8 as follows. Gentamicin induced nephrotoxicity in sprague dawley rats is. In this study we investigated the role of free radicals in gentamicin. Inhibitor of extracellular cysteine proteinase widely expressed by nucleated cells increased in. Research article renal protective effect of hesperidin on. Pdf in this study, we aimed to investigate the possible protective effect of resveratrol on. Effect of nacetylcysteine on gentamicin mediated nephropathy in. Pdf gentamicininduced nephrotoxicity in rats ameliorated and. Research article sildenafil ameliorates gentamicininduced. Effects of cosupplementation of vitamins e and c on. The aim of the present study was to evaluate the protective effect of crocin against gentamicininduced nephrotoxicity in rats. Gentamicin, cimetidine, losartan, vitamin e, rats, nephrotoxicity.
Quantitative evaluation of gentamicin induced structural alterations and degree of functional. Concurrent use of other potentially neurotoxic or nephrotoxic agents, or potent diuretics should be avoided. Effect of cimetidine on gentamicinlosartan induced. Nephrotoxicity is a significant adverse side effect of gentamicin. Gentamicininduced nephrotoxicity was indicated by the reduced renal function and renal oat3 function and expression. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal failure, that is, azotemia in the presence. Additionally, gentamicin induced tubular necrosis in rats kidneys, increased concentration of kim1 and ngal as well as parameters of renal. Vitamin bcomplex dosedependently ameliorated gentamicininduced nephrotoxicity in adult swiss albino rats when given intramuscularly. The protective effect of apo might be due to the reduction of the free. Gentamicininduced acute renal failure model a variety of exogenous mainly drugs or endogenous toxins cause acute kidney injury aki in humans and in experimental animals. Flavocoxid attenuates gentamicininduced nephrotoxicity in rats.
Taken together, pharmacological interventions like antioxidants, ros scavengers and antioxidant enzymes are able to prevent gentamicininduced nephrotoxicity. Group2 received gentamicin gm 80 mgkgd, for 8 days intraperitoneally. Gentamicin induced acute renal failure model a variety of exogenous mainly drugs or endogenous toxins cause acute kidney injury aki in humans and in experimental animals. Attenuation of gentamicininduced nephrotoxicity in rats. Mar 24, 2017 gentamicin induced nephrotoxicity has been extensively studied in the past and has become one of the established models of drug induced nephrotoxicity. Aug 08, 2016 nephrotoxicity was induced in rats by intraperitoneal injection i. Diagnosis and treatment aminoglycoside nephrotoxicity typically is associated with nonoliguric acute renal. Pdf influence of iron, deferoxamine and ascorbic acid on. Gentamicininduced apoptosis in renal cell lines and embryonic rat fibroblasts. Gentamicin gnt is an aminoglycoside antibiotic used for treatment of serious. Effect of dimethyl sulfoxide on gentamicin induced nephrotoxicity in rats. Osmotic diuresis with isosorbide did not significantly reduce the dosedependent extent of.
The effect of fleroxacin on gentamicin induced nephrotoxicity was evaluated with female spraguedawley rats. The aim of this study was to investigate the effects of manganese chloride on gentamicininduced nephrotoxicity in rats. Molecular mechanism of drug induced nephrotoxicity 1. Protective effects of curcumin on acute gentamicininduced. Pinocembrin attenuates gentamicininduced nephrotoxicity in. Gentamicininduced acute renal failure model creative biolabs. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats aged 1 and 24 months. Protective effect of nebivolol on gentamicininduced nephrotoxicity in rats article pdf available in bratislavske lekarske listy 11911. Research article open access hyperbaric oxygen treatment and nephrotoxicity induced by gentamicin in rats matitiahu berkovitch1,2, yossi shain1,2, eran kozer1,2, michael goldman1,2 and ibrahim abukishk1,2 abstract background. They were injected with gentamicin sulfate 100 mg kg. Effect of nacetylcysteine on gentamicinmediated nephropathy in. Protective effect of pongamia pinnata flowers against cisplatin and gentamicin induced nephrotoxicity in rats annie shirwaikarl, s malini2, s chandrika kumari i i department of pharmacognosy, college of pharm.
Gentamicin 30, 60, 120, 160 mgkg was administered s. Osmotic diuresis with isosorbide did not significantly reduce. Protective effect of transresveratrol on gentamicin. The effect of isosorbide diuresis on gentamicin excretion and tissue accumulation as well as gentamicin induced histopathologic changes in renal tissue were examined in rats. Thirtysix adult wistar albino rats were divided into six equal groups. Experimental gentamicin nephrotoxicity and agents that modify it. This study aimed to investigate the possible protective effect of apocynin apo on nephrotoxicity induced by gnt in rats.
Group3 and 4 received eeot 250 and 500 mgkgd, for 21 days orally plus gentamicin simultaneously. Gentamicininduced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the induction of superoxide anions. The present study was undertaken to evaluate the aqueous extract of k. The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated. Monitor renal and auditory function during therapy and discontinue therapy or adjust. The aim of the study was to investigate the renoprotective effect of hesperidin hdn, a citrus. Ethanolic extract of garlic for attenuation of gentamicin. Gentamicin gnt is an aminoglycoside antibiotic used for the treatment of serious grampositive and gramnegative bacterial infections. Aminoglycoside type antibiotic gentamicin is one of the leading cause of druginduced nephrotoxicity. The present results indicate that spironolactone aggravates gentamicin. Increased nephrotoxicity of gentamicin in pyelonephritic rats. Wistar albino rats of either sex were divided into four groups.
Quantitative evaluation of gentamicininduced structural alterations and degree of functional. Inhibitory effect of olive leaf extract on gentamicininduced. Gentamicininduced nephrotoxicity in rats ameliorated and healing effects of resveratrol. Rats were treated with curcumin 100 mgkg body mass by intragastric administration, once daily, followed with an intraperitoneal injection of gentamicin sulfate solution at a dose of 80 mgkg body mass for 8 consecutive days. The present study was designed to determine the protective effect of salicylic acid sa in gentamicin induced nephrotoxicity in rats. Gentamicin induced nephrotoxicity in rats albino rats 150200 g of either sex were used for the study. Nephrotoxicity was induced in rats by intraperitoneal injection i. This prompted a surge in research into the possible influences of certain agents that can ameliorate. Renal protective effect of hesperidin on gentamicin induced acute nephrotoxicity in male wistar albino rats. Sep 07, 2014 aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads.
Pdf protective effect of crocin on gentamicininduced. However, its usefulness is limited by nephrotoxicity, which may occur in 30% of treated patients mathew 1992. Protective effect of quercetin against gentamicin induced nephrotoxicity in rats. Aminoglycosideinduced nephrotoxicity article pdf available in journal of pharmacy practice 276 september 2014 with 1,253 reads how we measure reads. This study demonstrates an improvement in renal function in response to the administration of tr in gentamicininduced nephrotoxicity. Patients with impaired renal function, advanced age, dehydration, and those who receive high doses or prolonged therapy are at an increased risk of toxicity. Animal care was in compliance with the guidelines of the animal and. In other hand, gentamicin reduces efficiency in kidney antioxidant enzymes like superoxide dismutase sod, catalase cat, glutathione peroxidase gpx and glutathione gsh 7. For this purpose female spraguedawley rats were given intraperitoneally either gentamicin sulphate 40 mgkg, melatonin 10 mgkg, gentamicin plus melatonin or vehicle control twice.
Inhibitory effects of cinnamon extract on gentamicininduced. Department of biochemistry, faculty of pharmacy, october 6 th university, october 6 th city, egypt keywords. Renal protective effect of hesperidin on gentamicininduced acute. Pinocembrin attenuates gentamicininduced nephrotoxicity. Salicylic acid attenuates gentamicininduced nephrotoxicity. Pioglitazone attenuates kidney injury in an experimental model of. This article is from iranian journal of basic medical sciences, volume 16. Methods subjects male spraguedawley rats weighing 200300 g were housed under controlled environmental conditions 24 2 c and 12 h lightdark cycle and allowed free access to standard rat chow and tap water. Gentamicin 80 mg 1 kg 1 day for 6 days, intramuscularly produced the typical pattern of nephrotoxicity. Comparative study on gentamicin and streptomycin induced. Several parameters of renal function, histological changes on light and electron microscopy, and drug levels in renal parenchyma were com. Due to high relative blood flow the kidney is prone to druginduced damage. Effects of hydration on gentamicin excretion and renal accumulation in furosemidetreated rats.
Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. Cimetidine appears to have protective effect on gentamicinlosartaninduced nephrotoxicity in rats. Attenuation of gentamicininduced nephrotoxicity in rats by. We also investigated the effects of mt on induction of apoptotic cell death and its potential mechanisms in renal tissues in response to gm treatment. Gentamicin gm is a widely used antibiotic against serious and lifethreatening infections, but its usefulness is limited by the development of nephrotoxicity. Aminoglycoside nephrotoxicity kidney international. Renal protective effect of hesperidin on gentamicininduced acute nephrotoxicity in male wistar albino rats. Role of dl alphalipoic acid in gentamicin induced nephrotoxicity. Injection route solution therapy has been associated with potential neurotoxicity, ototoxicity, and nephrotoxicity. Melatonin attenuates gentamicininduced nephrotoxicity and. Pioglitazone attenuates kidney injury in an experimental. Gentamicin induced nephrotoxicity is a model of acute renal failure caused by oxidative stress generated through the induction of superoxide anions.
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